Thumbs.db is a Windows Xp file that is used to cache the thumbnails of a folder, and it can be very annoying to say the least. If you want to get rid of Thumbs.db take the following steps:

1. Open Windows Explorer.
2. Click Tools -> Folder Options -> Open the View tab.
3. Make sure that Do not cache thumbnails is checked.
4. Click the Apply to all folders button.
5. Click OK.